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Poster Walks: Poster Walk 8: Interstitial lung disease/ICU/Pediatrics |

P244 Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children

H.L. Chung; Y.Y. Jang
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School of Medicine, Pediatrics, Cathoilic University of Daegu, Daegu, Republic of Korea


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A144. doi:10.1016/j.chest.2017.04.151
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Introduction: The children with post-infectious bronchiolitis obliterans (PIBO) are frequently hospitalized with acute exacerbation, but clinical differentiation of PIBO exacerbation from ordinary bronchiolitis is often challenging, which may result in treatment delay and chronic lung function impairment. We aimed to examine whether serum YKL-40 and growth factors could be markers for PIBO exacerbation.

Methods: Thirty-seven children admitted with acute exacerbation of PIBO were enrolled. Diagnosis of PIBO was based on clinical history of acute respiratory infection followed by persistent airway obstruction and characteristic findings in high-resolution computed tomography. Serum levels of YKL-40, vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1 and platelet derived growth factor (PDGF)-BB were measured. The mediators were also examined in the children admitted with acute bronchiolitis serving as positive controls (N=30) and in age-matched controls (N=20).

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