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Poster Walks: Poster Walk 6: Basic Science/Pulmonary hypertension |

P217 Extravascular lung water in healthy lowlanders during repeated high altitude exposure

P.R. Bader; M. Lichtblau; M. Furian; L. Muralt; S.E. Hartmann; J.M. Rawling; M.J. Poulin; K.E. Bloch; S. Ulrich
Author and Funding Information

1Pulmonology, University Hospital Zurich, Zürich, Switzerland

2University of Calgary

3Family Medicine, University of Calgary, Calgary, Canada


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A116. doi:10.1016/j.chest.2017.04.122
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Introduction: High altitude pulmonary edema (HAPE) is a life-threatening condition associated with increasing extravascular lung water (EVLW). In healthy individuals, we investigated 1) whether EVLW is observed upon acute exposure to very high altitude; 2) changes in EVLW over a one-week stay at altitude; and 3) the effect of re-exposure on EVLW to the same altitude.

Methods: EVLW was assessed in twenty-one healthy lowlanders (living< 800m, mean±SD age 25±4 years, FEV1 96±12%predicted) by lung ultrasonography and quantified as lung comets during two consecutive sojourns to the ALMA Observatory (Atacama, Chile). Participants slept at 2900m and drove 45-minutes by car to 5050m on six consecutive days and stayed there for 6-8 hours. Measurement took place at low altitude (LA1; Santiago, 520m), and after the first and the sixth night at 5050m (HA1 and HA6, respectively). This cycle was repeated following an identical protocol, after 7-days rest at LA (i.e., cycle 2). ClinicalTrials.gov [NCT02760186].

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