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Poster Walks: Poster Walk 6: Basic Science/Pulmonary hypertension |

P214 Right-to-left shunt in patients with COPD at high altitude - a randomized, placebo-controlled trail with dexamethasone

M. Lichtblau; M. Furian; S. Aeschbacher; M. Bisang; M. Mademilov; U. Sheraliev; A. Tabysheva; B. Osmanov; H. Knapp; S. Ulrich; T. Sooronbaev; K.E. Bloch; S. Ulrich
Author and Funding Information

1Pulmonary Division and Sleep Disorders Center, University Hospital Zurich, Zürich, Switzerland

2National Centers for Cardiology and Internal Medicine, Bishkek, Kyrgyzstan


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A113. doi:10.1016/j.chest.2017.04.119
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Extract

Objective: To study the prevalence of right-to-left shunts (RLS) in patients with COPD traveling to altitude with and without dexamethasone prophylaxis. We hypothesized that hypobaric hypoxia would increase RLS and dexamethasone would be preventive.

Methods: Lowlanders with COPD, GOLD 1-2, SpO2 >93%, were randomized to Dexamethasone (4mg, bid) or placebo, starting one day before ascent from 760m and during a 3-day-stay at 3200m, Kyrgyztan. Resting and saline contrast echocardiography were performed at 760m and after the first night at 3200m. Shunt was defined by visible bubbles in the left atrium and classified as intracardiac (within 3 cardiac cycles) or intrapulmonary.

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