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Poster Walks: Poster Walk 6: Basic Science/Pulmonary hypertension |

P209 Effect of normobaric hypoxia on pulmonary hemodynamics in patients with precapillary pulmonary hypertension

A. Groth; P.R. Bader; M. Lichtblau; S. Saxer; M. Furian; S.R. Schneider; E.I. Schwarz; K.E. Bloch; S. Ulrich
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Pulmonology, University Hospital Zurich, Zürich, Switzerland


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A108. doi:10.1016/j.chest.2017.04.114
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Introduction: Patients with precapillary pulmonary hypertension (PH, pulmonary arterial or chronic thromboembolic pulmonary hypertension, PAH/CTEPH) may experience disease deterioration upon exposure to a hypoxic environment during air travel or altitude sojourns due to hypoxic pulmonary vasoconstriction. We investigated the effect of breathing a hypoxic air mixture on pulmonary hemodynamics and blood gases in PH in comparison with unaffected controls.

Methods: Patients scheduled for diagnostic right heart catheterization had hemodynamic assessments under ambient air (FiO2 0.21) and after 10 min of breathing nitrogen-enriched air (hypoxia FiO2 0.16). Patients were stratified according to their mean pulmonary arterial pressure (mPAP): PH (mPAP ≥25mmHg, pulmonary artery wedge pressure (PAWP) ≤15mmHg), unaffected controls (patients undergoing RHC for evaluation of dyspnea with mPAP< 20mmHg) and intermediate (mPAP 20-24mmHg).

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