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Poster Walks: Poster Walk 6: Basic Science/Pulmonary hypertension |

P204 Autophagic dysfunction is improved by the administration of the endoplasmic reticulum stress inhibitor trimethylamine-N-oxide in a murine model of neutrophilic asthma

B. Zhou
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Department of Respiratory Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A103. doi:10.1016/j.chest.2017.04.109
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Introduction: Autophagy and endoplasmic reticulum (ER) stress has been considered to be an important regulator of airway inflammation in the pathogenesis of eosinophil-dominant bronchial asthma, but the mechanisms involved in neutrophilic asthma remain not fully understood. In the present study, we assessed the effects of the endoplasmic reticulum inhibitor (trimethylamine-N-oxide, TMAO) on autophagic dysfunction and airway inflammation in the lung tissue of the neutrophilic asthma model (OVALPS-OVA mice) and in the bronchial epithelial cell model (tunicamycin-induced MLE-12).

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