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P183 Histiocytic sarcoma of interdigitating reticular cells in the mediastinum - case report

A. Miotto; J.M.A. Lopez; P.A.A. Honda; D.C.A. Dias; H.F. Costa; J.H. Rivaben; M. Botter
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Thoracic Surgery, Hospital Sancta Maggiore, Sao Paulo, Brazil


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A81. doi:10.1016/j.chest.2017.04.086
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Reticular dendritic cells are present in the germinal center of lymph nodes, with the function of pathogens phagocytation. They present antigens to B and T lymphocytes, acting, among other fronts, in the cellular memory. Histiocytic sarcoma is a rare malignant neoplasm with proliferation of cells with morphological and immunophenotypic characteristics of mature histiocytes derived from dendritic cells. In the mediastinum, histiocytic sarcoma of interdigitating reticular cells (HSIRC) are even more infrequent, with only 2 reports in the literature. Its histological diagnosis is considered a challenge, since it must be differentiated from other causes of mediastinal neoplasms, such as lymphomas, germinal tumors, and even lymph node metastases from carcinoma.

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