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P182 A preoperative nomogram for tumor regression grade following induction chemotherapy for esophageal squamous cell carcinoma

X.-Z. Kang; L. Dai; W.-P. Yan; Y.-B. Yang; H.-T. Zhou; H.-L. Yang; H. Fu; M.-Y. Fan; Y. Lin; Z. Liang; H.-C. Xiong; K.-N. Chen
Author and Funding Information

1Beijing Cancer Hospital, Thoracic Surgery, Peking University

2Department of Thoracic Surgery, Peking University Cancer Hospital, Beijing, China


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A80. doi:10.1016/j.chest.2017.04.085
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Introduction: To (1) evaluate the continuous distribution of tumor regression grade (TRG) in resection specimens after induction chemotherapy for locally advanced esophageal squamous cell carcinoma (ESCC), (2) determine the effects of TRG on survival after esophagectomy, and (3) identify preoperative predictors of TRG.

Methods: From June 2001 to October 2012, 212 patients underwent induction chemotherapy followed by esophagectomy for locally advanced ESCC. TRG, assessed as the percentage of residual primary ESCC cells in resection specimens, was classified histologically by pathologists. Random Forest technology was used for data analysis. A nomogram was developed allowing prediction of TRG through use of preoperative clinical factors for patients with clinically locally advanced ESCC who are candidates for treatment with a radical esophagectomy.

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