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P171 Predicting quality adjusted life years using St. George respiratory results in patients with severe emphysema

T. Morton; R. Evans; M. Brutsche; R. Busca; G. Deslee; A. De Soyza; J.-M. Fellrath; D. Franzen; J. Hartman; S. Mealing; M. Munavvar; M. Sculpher; P.L. Shah; D.-J. Slebos; I. Durand-Zaleski
Author and Funding Information

1ICON Health Economics & Epidemiology, Oxford, United Kingdom

2Kantonsspital St. Gallen, St. Gallen, Switzerland

3PneumRx Ltd, a BTG International company, London, United Kingdom

4University Hospital, Reims, France

5NewCastle, London, United Kingdom

6Hôpital Neuchâtelois-Pourtalès, Neuchatel

7University Hospital Zurich, Zurich, Switzerland

8University Medical Center, Groningen, The Netherlands

9Royal Preston Hospital, London

10University of York, York

11The National Institute for Health Research Unit, Royal Brompton & Harefield NHS Foundation Trust, and Imperial College, London, United Kingdom

12URCEco Ile de France Hôpital de l'Hotel Dieu, Paris, France


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A69. doi:10.1016/j.chest.2017.04.074
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Extract

Introduction: End-stage emphysema is associated with severe dyspnoea, limitation of activities, recurrent lung infection and, ultimately, respiratory failure. The PneumRx Endobronchial Coil System is a minimally invasive treatment option for severe emphysema. At the individual patient level Health Related Quality of Life (HRQoL) is important in assessment of limitations, disease course over time, and the effects of interventions. The RENEW study was a randomised controlled study with lung volume reduction coils in patients with severe emphysema (NCT01608490). Quality-Adjusted Life Years (QALYs) a metric that combines quality and quantity of life is an important measure of patient benefit. The reported mean 1-year QALY difference in another coil RCT [REVOLENS] was 0.06. The purposes of this analysis were to: i) map available SGRQ data onto EQ5D preference (utility) values; ii) generate prognostic statistical models to quantify the impact of coils treatment on HRQoL; iii) generate indicative estimates of long-term QALY gains over a range of clinically plausible scenarios.

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