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P159 Effects of subacute hypobaric hypoxia on human respiratory muscle function and diaphragm morphology

J. Pichler Hefti; H.-J. Kabitz; C.T. Nakas; D. Berger; U. Hefti; T.M. Merz
Author and Funding Information

1Department of Pneumology, Inselspital, University Hospital Bern, Bern, Switzerland

2Department of Internal Medicine II, Pneumology and Intensive Care Medicine, Academic Teaching Hospital Konstanz, Konstanz, Germany

3Institute of Clinical Chemistry, Inselspital, Bern University Hospital, Bern, Switzerland

4Laboratory of Biometry, University of Thessaly, Volos, Greece

5Department of Intesive Care Medicine, Inselspital, University Hospital Bern

6Swiss Sportclinic, Bern, Switzerland


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A57. doi:10.1016/j.chest.2017.04.061
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Extract

Introduction: Respiratory - especially diaphragmatic - muscle function is of utmost importance in the context of hypoxia of any type to compensate for the increased ventilatory demand. Data from short-term exposure to moderate hypoxia suggest a decrease in respiratory muscle strength and increased fatigability during exercise. This study examined the effects of severe and prolonged hypobaric hypoxia on respiratory muscle strength in addition to diaphragmatic function and morphology during a high altitude expedition.

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