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Poster Walks: Poster Walk 3: Sleep/Breathing |

P154 Effect of CPAP treatment for obstructive sleep apnea on long-term functional outcome in patients with ischemic stroke/TIA - A randomized controlled interventional trial (SAS-Care-2 Study)

S. Ott; C. Carlo; C. Bernasconi; P. Young; L. Nobili; M. Manconi; C. Bassetti
Author and Funding Information

1Universitätsklinik für Pneumologie, Universitätsspital Bern (Inselspital), Bern

2Stroke Center, Neurocenter of Southern Switzerland, Lugano

3Neurology, University Hospital and University of Bern, Bern, Switzerland

4University Münster, Münster, Germany

5University Milano, Milano, Italy

6Neurocenter of Southern Switzerland, Lugano, Switzerland


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A52. doi:10.1016/j.chest.2017.04.056
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Background and aims: Obstructive sleep apnea (OSA) is frequent in ischemic stroke/TIA patients and may negatively affect functional outcome. Little is known about the effect of OSA treatment on the long-term outcome following ischemic stroke/TIA. We aimed to assess prospectively the effect of CPAP treatment for moderate to severe OSA on long-term stroke outcome.

Methods: Patients with ischemic stroke/TIA and OSA (AHI ≥20/h) 3 months after the acute event were included in an international multicenter trial (SAS-CARE-2). Sleepy patients (ESS ≥10) were directly assigned to CPAP treatment and non-sleepy patients (ESS < 10) were randomized to either CPAP or no OSA treatment (CPAP-). Patients with AHI < 20/h were followed observationally. Stroke outcome was determined by the modified Rankin Scale (mRS) at CPAP-initiation and after 6, 12, and 24 months.

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