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Poster Walks: Poster Walk 2: Airway disease II |

P151 Endothelial dysfunction, disease severity and outcome in moderate to severe COPD

A. Scherr; D. Schumann; W. Strobel; M. Tamm; D. Stolz
Author and Funding Information

Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A49. doi:10.1016/j.chest.2017.04.052
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Extract

Introduction: Chronic obstructive pulmonary disease is significantly associated with extra-pulmonary comorbid conditions such as cardiovascular and peripheral vascular disease. It has been hypothesized that local airway inflammation may cause changes in systemic circulation which result in vascular changes, namely, endothelial dysfunction. The measurement of endothelial dysfunction using reactive hyperemia peripheral arterial tonometry (RH-PAT) is well documented in the field of cardiovascular research. There are no data available for COPD patients. We, therefore, investigated endothelial dysfunction in a cohort of COPD patients using RH-PAT to determine the importance of endothelial dysfunction in assessing disease severity and systemic burden in COPD.

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