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Poster Walks: Poster Walk 2: Airway disease II |

P145 Modeling of oxygen recovery after 6-min walk tests in COPD

F. Baty; C. Ritz; L. Kern; S.M. Jensen; M. Brutsche
Author and Funding Information

1Pulmonary Medicine, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland

2Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A42. doi:10.1016/j.chest.2017.04.046
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Introduction: 6-min walk tests (6MWT) are routinely performed in patients with chronic obstructive pulmonary diseases (COPD). Oxygen (VO2) kinetics during 6MWT can be modeled and derived parameters provide indicators of patients' exercise capacity. Post-exercise VO2 recovery has not been extensively investigated. A number of nonlinear regression models with partly different underlying biological assumptions and mechanisms may be suitable for describing recovery kinetics. Subsequently, model averaging can be used to capture the uncertainty in considering several models. We applied model averaging in the context of nonlinear mixed effects regression to describe and better understand the physiological underpinnings of the VO2 recovery after 6MWT in patients with COPD.

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