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P142 IFNL3 polymorphisms and circulating levels are associated with COPD severity and outcomes

A. Egli; D.M. Schumann; J. Mandal; M. Roth; B. Thomas; L. Tyrrell; F. Blasi; K. Kostikas; W. Boersma; B. Milenkovic; A. Lacoma; G.G.U. Rohde; R. Louis; J.G. Aerts; T. Welte; A. Torres; M. Tamm; D. Stolz
Author and Funding Information

1Applied Microbiology Research

2Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland

3Li Ka Shing Institute for Virology, University of Alberta, Edmonton, Canada

4Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Milan, Italy

5Department of Pneumology, University of Thessaly Medical School, Larissa, Greece

6Department of Pneumology, Medisch Centrum Alkmaar, Alkmaar, The Netherlands

7Department of Pneumology, Institute for Pulmonary Diseases, Belgrade, Serbia

8Department of Microbiology, Hospital General de México ‘Eduardo Liceaga’Universitari Germans Trias i Pujol, Badalona, Spain

9Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands

10Department of Pneumology, CHU Liege University of Liege, Liege, Belgium

11Department of Pneumology, Amphia Hospital, Breda, The Netherlands

12Department of Pneumology, Medizinische Hochschule Hannover, Hannover, Germany

13Department of Pneumology, Hospital Clinic, Barcelona, Spain


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A39. doi:10.1016/j.chest.2017.04.043
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Extract

Introduction: Exacerbation of chronic obstructive pulmonary disease (COPD) is associated with high morbidity and mortality. Interferon lambda (IFNL) has an important anti-viral/bacterial and immunomodulatory function in the respiratory tract. However, the impact of IFNLs in the context of COPD and its exacerbations has not been explored yet.

Material and methods: We determined the genetic polymorphisms (rs8099917 and rs12979860) within the IFNL3/4 gene region and the circulating levels of IFNL3 in COPD patients recruited in a prospective observational multicentre cohort (PROMISE) study. The genotypes and the circulating levels of INFL3 were associated with disease activity and outcome parameters during a median follow-up of 24 months.

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