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Oral Sessions: Session 20: Free Communications - Lung cancer and thoracic surgery |

124 Plasma thioredoxin reductase 1 as a diagnostic marker for non-small cell lung cancer

X. Kang; C. Dong; B.-C. Shen; L. Dai; W.-P. Yan; Y.-B. Yang; H. Yin; G. Xu; H. Zeng; K.-N. Chen
Author and Funding Information

1Department of Thoracic Surgery, Peking University Cancer Hospital

2State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center

3Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University

4Department of Clinical Laboratory, Peking University Cancer Hospital, Beijing

5Keaise Center for Clinical Laboratory, Wuhan, China


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A21. doi:10.1016/j.chest.2017.04.023
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Extract

Introduction: Non-invasive diagnostic markers for patients with suspicious non-small cell lung cancer (NSCLC) may provide needed guidance on invasive diagnostic and therapeutic decisions. Thioredoxin reductase 1 (TrxR1) is a pivotal intracellular redox sensor and antioxidant enzyme, and plays an important part in tumor growth, progression, metastasis, and chemotherapy resistance. The goal of this study is to test the feasibility of developing plasma TrxR1 as a novel diagnostic marker for NSCLC.

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