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Oral Sessions: Session 19: Free Communications - Interstitial lung disease, translational research and pulmonary hypertension |

119 Exhaled breath analysis by real-time mass spectrometry in patients with pulmonary fibrosis

P. Sinues; Y. Nussbaumer-Ochsner; M.T. Gaugg; L. Bregy; A. Engler; R. Zenobi; M. Kohler
Author and Funding Information

1Chemistry & Applied Biosciences, ETH Zurich

2Department of Pulmonology, University Hospital of Zurich

3Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A16. doi:10.1016/j.chest.2017.04.017
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Introduction: Idiopathic pulmonary fibrosis (IPF) is recognized as a distinct clinical disorder. However, despite major endeavors to understand the pathogenesis, the diagnosis of IPF remains elusive [1]. Metabolic profiling of biopsied tissue specimens has been shown promise to gain insights into IPF pathogenesis [2]. Thus we hypothesized that analysis of exhaled metabolites may also provide further insights.

Methods: 21 patients with IPF and 21 matched controls were recruited for this exploratory study. Exhaled breath analysis was performed by Secondary Electrospray Ionization-Mass Spectrometry (SESI-MS) [3]. Significant differences in exhaled metabolite levels in IPF were subsequently sought. A two-sample t-test followed by estimation of false discovery rate in multiple comparisons was used for this purpose. Statistical significance was set at p < 0.05. Finally, we attempted to predict IPF vs control in a leave-one-out-cross-validation (LOOCV) using a set of 15 metabolites per sample predicted.

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