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Oral Sessions: Session 19: Free Communications - Interstitial lung disease, translational research and pulmonary hypertension |

118 Lung-derived mesenchymal stem cells exert anti-fibrotic effects in vitro

P. Khan; A. Gazdhar; S. Savic; D. Lardinois; M. Roth; M. Tamm; T. Geiser; K.E. Hostettler
Author and Funding Information

1Department of Biomedicine, University Hospital Basel, Basel

2Division of Pulmonary Medicine, University Hospital Bern, Bern

3Department of Pathology

4Division of Thoracic Surgery

5Clinics of Respiratory Medicine and Department of Biomedicine, University Hospital Basel, Basel, Switzerland


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A15. doi:10.1016/j.chest.2017.04.016
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Introduction: Idiopathic pulmonary fibrosis (IPF) is associated with damaged alveolar epithelial cells and an excessive proliferation and extracellular matrix deposition by fibroblasts. Stem cell-based therapy is a promising approach in the treatment of IPF. The therapeutic effects of stem cells are, at least in parts, mediated by the stem cell derived secretome through paracrine signaling. In this study we isolated mesenchymal stem cells (MSC) from fibrotic human lung tissue and investigated the anti-fibrotic properties of their secretome in vitro.

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