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Oral Sessions: Session 19: Free Communications - Interstitial lung disease, translational research and pulmonary hypertension |

117 Serum levels of glycosaminoglycans are altered during acute exacerbations in chronic obstructive pulmonary disease

E. Papakonstantinou; I. Bonovolias; M. Roth; F. Blasi; L. Boeck; A. Scherr; J. Rakic; R. Louis; B. Milenkovic; W. Boersma; K. Kostikas; J.G. Aerts; G.G.U. Rohde; A. Lacoma; A. Torres; T. Welte; M. Tamm; D. Stolz
Author and Funding Information

1Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland

2Department of Pharmacology, Aristotle University of Thessaloniki, Thessaloniki, Greece

3Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Milan, Italy

4Department of Pneumology, CHU Liege University of Liege, Liege, Belgium

5Department of Pneumology, Institute for Pulmonary Diseases, Belgrade, Serbia

6Department of Pneumology, Medisch Centrum Alkmaar, Alkmaar, The Netherlands

7Department of Pneumology, University of Thessaly Medical School, Larissa, Greece

8Department of Pneumology, Amphia Hospital, Breda

9Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands

10Department of Microbiology, Hospital General de México ‘Eduardo Liceaga'Universitari Germans Trias i Pujol, Badalona

11Department of Pneumology, Hospital Clinic, Barcelona, Spain

12Department of Pneumology, Medizinische Hochschule Hannover, Hannover, Germany


Copyright 2017, American College of Chest Physicians and Swiss Respiratory Society SGP. All Rights Reserved.


Chest. 2017;151(5_S):A14. doi:10.1016/j.chest.2017.04.015
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Introduction: COPD is an inflammatory condition associated with disturbance of the homeostasis of extracellular matrix (ECM) molecules contributing to airway remodeling. In the lung, the ECM is subjected to a daily turnover of about 10%. Among other ECM molecules, glycosaminoglycans (GAGs) play a key role in airway remodeling in COPD. The aim of our study was to investigate whether serum levels of various GAGs are altered during acute exacerbation of COPD.

Methods: This is a prospective, observational, multicenter study including 506 patients with COPD, GOLD stages II-IV, >10 PY seeking care in pulmonary tertiary hospitals in 8 European countries and included in the PROMISE cohort. The primary outcome of the study was exacerbation and/or death. Median observation time was 24 months. Serum levels of hyaluronic acid (HA), heparan sulfate (HS) and chondroitin sulfate (CS) were measured by ELISA in patients with COPD at stable state (n=206), at exacerbation (moderate n=162; severe n=88) and 4 weeks after exacerbation (n=152).

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