0
Original Research |

How well does CAPTURE™ Translate? An Exploratory Analysis of a COPD Case-Finding Method for Spanish-Speaking Patients

Wilson A. Quezada, MD; Beth A. Whippo, MSN; Patricia A. Jellen, MSN; Nancy K. Leidy, PhD; David Mannino, MD; Katherine J. Kim, MPH; MeiLan K. Han, MD, MS; Julia F. Houfek, PhD; Barry Make, MD; Karen G. Malley, BA; Catherine A. Meldrum, PhD; Stephen Rennard, MD; Barbara P. Yawn, MD MSc; Fernando Martinez, MD; Byron M. Thomashow, MD
Author and Funding Information

Target Journal: Chest

Fundinginformation: Funding for this work was provided by the National Heart, Lung, and Blood Institute NHLBI: R01 HL 114055.

Conflict of Interest Disclosure:

All COI disclosures are included on a separate page due to length.

Clinical Trial Registration: NCT01880177 https://clinicaltrials.gov/ct2/show/NCT01880177?term=NCT01880177&rank=1

1Columbia University, New York, NY

2New York Presbyterian Hospital/Columbia University Medical Center, New York, NY

3Evidera, Bethesda, MD

4University of Kentucky, Lexington, KY

5University of Michigan, Ann Arbor MI

6University of Nebraska, Omaha NE

7National Jewish Health, Denver CO

8AstraZeneca, Cambridge, UK

9University of Minnesota, Minneapolis MN

10Cornell University, New York, NY

Corresponding Author: Fernando Martinez, MD, MS Executive Vice Chairman Gladys and Roland Harriman Professor of Medicine Joan and Sanford I. Weill Department of Medicine Weill Cornell Medical College New York-Presbyterian Hospital/Weill Cornell Medical Center 525 East 68th St, Room M-522, Box 130 New York, NY 10065.


Copyright 2017, . All Rights Reserved.


Chest. 2017. doi:10.1016/j.chest.2017.03.047
Text Size: A A A
Published online

Abstract

Background  This study tested the properties of a Spanish translation of CAPTURE™ (COPD Assessment in Primary Care To Identify Undiagnosed Respiratory Disease and Exacerbation Risk) with selective use of peak expiratory flow (PEF).

Methods  Analyses of data from the Spanish-speaking cohort of the cross-sectional, case-control study used to develop CAPTURE. Translation procedures included forward and backward translation, reconciliation, and cognitive interviewing to assure linguistic and cultural equivalence. Spanish-speaking participants were recruited through one center and designated as Cases (clinically significant COPD: FEV1 < 60% predicted and/or at risk of COPD exacerbation) or Controls (No or mild COPD). Subjects completed a questionnaire booklet that included 44 candidate items, COPD Assessment Test (CAT), and modified Medical Research Council (mMRC) dyspnea question. PEF and spirometry were also performed.

Results  N=30 participants: 17 cases; 13 controls. Mean (SD) age: 62.6 (11.49) years; 33% male. CAPTURE-S scores were significantly correlated with PEF (r=-0.78), FEV1/FVC ratio (r=-0.74), FEV1r= (-0.69), FEV1% predicted (r=-0.69), CAT score (r=0.70), and mMRC (r=0.59) (p<0.0001), with significantly higher scores in cases than controls (t=6.16, p<0.0001). PEF significantly correlated with FEV1 (r=0.89), FEV1 % predicted (r=0.79), and FEV1/FVC (r=0.75) (p<0.0001), with significantly lower PEF in cases than controls (t=5.08, p<0.0001). CAPTURE-S score plus PEF differentiated cases and controls with sensitivity = 88.2% and specificity = 92.3%.

Conclusions  CAPTURE-S with selective use of PEF appears to be useful for identifying Spanish-speaking patients in need of diagnostic evaluation for clinically significant COPD who may benefit from initiation of COPD treatment.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543