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Original Research |

Restrictive Spirometry Pattern is Associated with Increased Arterial Stiffness in Men and Women

I-Hsuan Wu; Zih-Jie Sun; Feng-Hwa Lu; Yi-Ching Yang; Chieh-Ying Chou; Chih-Jen Chang; Jin-Shang Wu
Author and Funding Information

Conflict of interest:

The authors declare no conflict of interest.

1Department of Family Medicine, National Cheng Kung University Hospital

2Department of Family Medicine, College of Medicine, National Cheng Kung University

3Department of Family Medicine, National Cheng Kung University Hospital, Dou-Liou Branch

Corresponding author : Jin-Shang Wu Department of Family Medicine, National Cheng Kung University and Hospital, 138, Sheng Li Road, Tainan, Taiwan, R.O.C.

∗∗Co-corresponding author: Feng-Hwa Lu.


Copyright 2017, . All Rights Reserved.


Chest. 2017. doi:10.1016/j.chest.2017.03.039
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Abstract

Background  There is growing evidence that pulmonary function impairment has been found to be related to cardiovascular events and death. Some studies showed that the level of forced vital capacity (FVC) was negatively related to arterial stiffness, but most studies were confined to males and none of them examined the association of the presence of restrictive spirometry pattern with arterial stiffness. Therefore, this study aimed to investigate the association of restrictive spirometry pattern with arterial stiffness by gender.

Methods  This study recruited 2,961 subjects after excluding those with 1) obstructive lung disease, as defined by history and pulmonary function test; 2) history of asthma, lung cancer, tuberculosis, coronary heart disease, stroke or any pulmonary structural deformities, and 3) medications influencing blood pressure, plasma glucose, lipid profile and pulmonary function test. Restrictive spirometry pattern was diagnosed as an FVC<80% of the predicted value and FEV1/FVC ratio ≥70%. Increased arterial stiffness was defined as right brachial ankle pulse wave velocity (baPWV) ≥1400cm/sec.

Results  In both males and females FVC was negatively associated with the baPWV level. Restrictive spirometry pattern was positively associated with increased arterial stiffness in both males and females (males: odds ratio: 2.16, 95% CI: 1.33 - 3.50; females: 1.95, 95% CI: 1.02 - 3.72) after adjustment for other clinical variables.

Conclusions  Both restrictive spirometry pattern and reduced FVC were associated with a higher risk of arterial stiffness, not only in males but also in females. Clinically, assessment of arterial stiffness might be considered in individuals with restrictive spirometry pattern.


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