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Recent Advances in Chest Medicine |

The Role of Infection in Interstitial Lung Diseases – A Review

Natalya Azadeh, MD, MPH; Andrew H. Limper, MD; Eva M. Carmona, MD, Ph.D; Jay H. Ryu, MD
Author and Funding Information

Conflict of interest: None

Funding: None

1Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester MN

Address all correspondences to: Natalya Azadeh, MD, MPH, Division of Pulmonary and Critical Care Medicine, Gonda 18 South, Mayo Clinic, 200 First St. SW, Rochester, MN 55905.


Copyright 2017, . All Rights Reserved.


Chest. 2017. doi:10.1016/j.chest.2017.03.033
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Abstract

Interstitial lung diseases (ILD) comprise an array of heterogeneous parenchymal lung diseases that are associated with a spectrum of pathologic, radiologic and clinical manifestations. There are ILDs with known etiologies and those that are idiopathic, making treatment strategies challenging. Prognosis can vary according to the type of ILD but many exhibit gradual progression with an unpredictable clinical course in individual patients as seen in idiopathic pulmonary fibrosis and the phenomenon of “acute exacerbation”(AE). Given the often poor prognosis of these patients the search for a reversible cause of respiratory worsening remains paramount. Infections have been theorized to play a role in ILDs; both in the pathogenesis of ILD and as potential triggers of AE. Research efforts thus far have shown the highest association with viral pathogens, however, fungal and bacterial organisms have also been implicated. This review aims to summarize the current knowledge on the role of infections in the setting of ILD.


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