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Recent Advances in Chest Medicine |

The Diagnosis and Management of Airway Complications Following Lung Transplantation

Amit K. Mahajan, MD; Erik Folch, MD; Sandeep J. Khandhar, MD; Colleen L. Channick, MD; Jose F. Santacruz, MD; Atul C. Mehta, MD; Steven D. Nathan, MD
Author and Funding Information

* We declare that we have no conflicts of interest

** Each author has contributed equally to this manuscript

*** This manuscript has not been submitted for publication in any other journals

Medical Director, Interventional Pulmonology, Inova Heart and Vascular Institute, Inova Fairfax Hospital, Falls Church, VA

Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston MA

Medical Director, Thoracic Surgery, Inova Heart and Vascular Institute, Inova Fairfax Hospital, Virginia Common Wealth Medical School, Falls Church, VA

Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA

Medical Director, Interventional Pulmonology, Houston Methodist Lung Center, Houston Methodist Hospital, Houston, TX

Professor of Medicine, Lerner College of Medicine, Buoncore Family Endowed Chair in Lung Transplantation, Staff, Department of Pulmonary Medicine, Respiratory, Institute
Cleveland Clinic, Cleveland, Ohio

Medical Director Advanced Lung Disease & Transplant Program, Inova Fairfax Hospital, Falls Church, VA


Copyright 2017, . All Rights Reserved.


Chest. 2017. doi:10.1016/j.chest.2017.02.021
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Published online

Abstract

Airway complications following lung transplantation result in considerable morbidity and are associated with a mortality of 2-4 percent. The incidence of lethal and non-lethal airway complications has decreased since the early experiences with double- and single-lung transplantation. The most common risk factor associated with post-lung transplant airway complications is anastomotic ischemia. Airway complications include development of exophytic granulation tissue, bronchial stenosis, bronchomalacia, airway fistula, endobronchial infection, and anastomotic dehiscence. The broadening array of bronchoscopic therapies has enhanced treatment options for lung transplant recipients with airway complications. This article reviews the risk factors, clinical manifestations, and treatments of airway complications following lung transplantation, and provides our expert opinion where evidence is lacking.


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