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Ex Vivo Lung Perfusion: A Key Tool for Translational Science in the Lungs

Shinya Tane, MD PhD; Kentaro Noda, PhD; Norihisa Shigemura, MD PhD
Author and Funding Information

Conflict of interest:

All authors declare no conflict of interests.

Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center

Correspondence to: Norihisa Shigemura, MD, PhD. Associate Professor of Cardiothoracic Surgery Director of Integrated Lung Transplant Research Program University of Pittsburgh Medical Center, Address) UPMC Presbyterian, Suite C-900, 200 Lothrop Street, Pittsburgh, PA 15213.


Copyright 2017, . All Rights Reserved.


Chest. 2017. doi:10.1016/j.chest.2017.02.018
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Abstract

Ex vivo lung perfusion (EVLP) promises to be a comprehensive platform for assessment, re-conditioning, and preservation for donor lungs and has been dramatically changing the face of clinical lung transplantation. Besides its increasing role in lung transplantation, EVLP has also been recognized as a useful tool for translational research involving the lungs. Based on recent remarkable evidence and experience using EVLP in lung transplantation, there is growing interest in and expectations for the use of EVLP beyond the field of lung transplantation. By combining EVLP with advances in regenerative medicine, stem cell biology, and oncology, the evolving technology of EVLP has a tremendous potential to advance pulmonary medicine and science. In this review, we revisit recent advances in EVLP technology and research and discuss the future translation of EVLP applications into life-changing medicine.


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