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Original Research |

Prophylactic corticosteroids for prevention of post-extubation stridor and reintubation in adults: a systematic review and meta-analysis

Akira Kuriyama, MD, MPH; Noriyuki Umakoshi, MD; Rao Sun, MD
Author and Funding Information

Conflict of interest: None for all authors.

Funding information: None.

Department of General Medicine, Kurashiki Central Hospital, 1-1-1 Miwa Kurashiki Okayama 710-8602 JAPAN

Department of General Medicine, Kurashiki Central Hospital, 1-1-1 Miwa Kurashiki Okayama 710-8602 JAPAN

Department of Anesthesiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China, 321 Zhongshan Road, Nanjing 210008 China

Corresponding author: Akira Kuriyama, MD, MPH, Department of General Medicine, Kurashiki Central Hospital, 1-1-1 Miwa Kurashiki Okayama 710-8602 JAPAN.


Copyright 2017, . All Rights Reserved.


Chest. 2017. doi:10.1016/j.chest.2017.02.017
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Published online

Abstract

Background  Corticosteroid administration before elective extubation has been employed to prevent post-extubation stridor and reintubation. We updated a systematic review to identify which patients would benefit from prophylactic corticosteroids before elective extubation.

Methods  We searched PubMed, EMBASE, the Wanfang Database, the China Academic Journal Network Publishing Database, and the Cochrane Central Register of Controlled Trials for eligible trials from inception through February 29, 2016. All randomized controlled trials were eligible if they examined the efficacy and safety of systemic corticosteroids given prior to elective extubation in mechanically ventilated adults. We pooled data using the DerSimonian and Laird random effects model.

Results  We identified 11 trials involving 2472 participants for analysis. Use of prophylactic corticosteroids was associated with a reduced incidence of post-extubation airway events [risk ratio (RR) 0.43, 95% CI 0.29–0.66] and reintubation (RR 0.42, 95% CI 0.25–0.71) compared with placebo or no treatment. This association was prominent in participants at high risk for developing post-extubation airway complications, defined using cuff-leak test, with a reduced incidence of post-extubation airway events (RR 0.34, 95% CI 0.24–0.48) and reintubation (RR 0.35, 95% CI 0.20– 0.64). This association was not found in trials with unselected participants. Adverse events were rare.

Conclusions  Administration of prophylactic corticosteroids before elective extubation was associated with significant reductions in the incidence of post-extubation airway events and reintubation, with few adverse events. It is reasonable to select patients at high risk for airway obstruction who may benefit from prophylactic corticosteroids.


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