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Pulmonary Eosinophilia From Inhaled Colistin

Pierre-Alexis Lépine, MD; Alain Dumas, B Pharm, MSc; Louis-Philippe Boulet, MD, FCCP
Author and Funding Information

Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ), Université Laval, Québec City, Québec, Canada

CORRESPONDENCE TO: Louis-Philippe Boulet, MD, FCCP, Institut universitaire de cardiologie et de pneumologie de Québec, 2725, Chemin Sainte-Foy, Québec City, Québec, Canada G1V 4G5


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2017;151(1):e1-e3. doi:10.1016/j.chest.2016.07.001
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We report the case of a patient with a history of chronic bronchiectasis that presented with new onset fatigue, shortness of breath, peripheral blood eosinophilia and infiltrates on chest radiograph. Eight days previously, she was prescribed inhaled colistimethate sodium 75 mg bid to prevent exacerbations of her respiratory condition. To our knowledge, our case is the first to show the clinical and radiologic features of inhaled-colistimethate-induced pulmonary eosinophilia. It also shows the rapid resolution of its features following treatment with oral corticosteroids. Eosinophilic lung reaction to inhaled colistin is rarely reported in the literature. Clinicians should be aware of this possible side effect.

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