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Contemporary Reviews in Sleep Medicine |

Control of Ventilation in Health and Disease

Susmita Chowdhuri, M.D., M.S.; M.Safwan Badr, M.D
Author and Funding Information

Conflict of interest:

S. Chowdhuri None, M.S. Badr None

1John D. Dingell VA Medical Center

2Wayne State University, Detroit MI

Corresponding author: SUSMITA CHOWDHURI 4646 John R (11M) Medical Service Detroit, MI 48201.


Copyright 2016, . All Rights Reserved.


Chest. 2016. doi:10.1016/j.chest.2016.12.002
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Abstract

Control of ventilation occurs at different levels of the respiratory system via a negative feedback system that allows for precise regulation of levels of arterial carbon dioxide and oxygen. Mechanisms for ventilatory instability leading to sleep disordered breathing include changes in respiratory rhythm genesis and chemoresponsiveness to hypoxia and hypercapnia, cerebrovascular reactivity, abnormal chest wall and airway reflexes, and sleep state oscillations. One can potentially stabilize breathing during sleep-related breathing disorders by identifying one or more of these pathophysiological mechanisms. This review describes the current concepts in ventilatory control that pertain to breathing instability during wakefulness and sleep, delineates potential avenues for alternative therapies to stabilize breathing during sleep and proposes recommendations for future research.


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respiration

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