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Original Research |

What has been researched in childhood obstructive sleep-disordered breathing: a systematic review

Roderick P. Venekamp, PhD; Deepak Chandrasekharan, MD; Francois Abel, MD; Helen Blackshaw, PhD; Irene A. Kreis, PhD; Hannah Evans, MSc; Anne GM. Schilder, PhD
Author and Funding Information

Summary conflict of interest statement

All authors declare no support from any organisation for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work.

Funding

evidENT at University College London is supported by a National Institute for Health Research (NIHR) Research Professorship award to Anne GM Schilder. Deepak Chandrasekharan is supported by an NIHR Academic Clinical Fellowship. Expert systematic review advice from Irene Kreis was made available through a Royal College of Surgeons of England Clinical Trials Initiative award. These organisations did not participate in the design of the review, collection, management, analysis and interpretation of the data, nor did it have a role in the preparation, review or approval of the manuscript. All authors were independent from the funder and had access to all the data.

Presentation, European Society of Paediatric Otorhinolaryngogy 2016 meeting, Lisbon, Portugal, 18-21 June 2016

Presentation, British Academic Conference in Otolaryngology, BAPO session, Liverpool, UK, 8-10 July 2015

Registration: PROSPERO, registration number CRD42015029291.

1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

2evidENT, Ear institute, University College London, Royal National Throat Nose and Ear Hospital, United Kingdom

3Respiratory Department, Great Ormond Street Hospital for Children, London, United Kingdom

4Clinical Effectiveness Unit, Royal College of Surgeons England, London, United Kingdom

Corresponding author Anne GM Schilder evidENT, Ear institute, University College London, Royal National Throat Nose and Ear Hospital, 330 Gray's Inn Road, London WC1X 8DA, United Kingdom.


Copyright 2016, . All Rights Reserved.


Chest. 2016. doi:10.1016/j.chest.2016.12.001
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Abstract

Background  Despite recent clinical guideline development, the best pathway of care for children with symptoms of obstructive sleep-disordered breathing (oSDB) is still debated. This systematic review aims to map research in childhood oSDB conducted so far, to support further guideline development, identify evidence gaps and guide future research.

Methods  Systematic search of PubMed, Embase, and Cochrane Library from inception to 26 November 2015. All publications on childhood oSDB were included, irrespective of type and language. The annual number of publications in the field of oSDB was counted over all years; for those published since 1 January 2011 (i.e. date of latest literature search of American Academy of Pediatrics guideline), total and annual numbers of publications across main research themes and methodologies were calculated.

Results  Of the 7637 unique records retrieved, 5871 publications were eligible for inclusion. There is an increase in annual publications since 2000, with 46% published since 2011. Most (61%) publications focused on individual treatment modalities, incidence or prognosis. Few (2.7%) publications focused on health service delivery, outcomes and health economics. 78.5% of publications were observational, 2.4% were randomised controlled trials and 0.4% used a qualitative approach as their main methodology.

Conclusions  A recent surge in research activity in childhood oSDB has improved the knowledge base for this condition; the lack of health services, health economics and outcomes research however impacts on the applicability of evidence informing current guidance and leaves important questions for future research.


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