0
Original Research |

Short-term effects of supplemental oxygen on 6-minute walk test outcomes in COPD patients - a randomized, placebo-controlled, single-blind, cross-over trial

Inga Jarosch, MSc; Rainer Gloeckl, Ph.D.; Eva Damm, MD; Anna-Lena Schwedhelm; David Buhrow; Andreas Jerrentrup, MD; Martijn A. Spruit, Ph.D., P.T., F.E.R.S.; Klaus Kenn, Prof.
Author and Funding Information

Summary conflicts of interest statements:

IJ and KK report grants for the clinic from ROX medical, California, USA, and study material (gases) from Linde Gas Therapeutics GmbH, Germany, during the conduct of the study. Outside the submitted work, MAS discloses receiving personal remuneration in the last two years for consultancy from Boehringer Ingelheim and GSK. RG, ED, AS, DB, and AJ have nothing to disclose.

Funding information:

The study was partly supported by ROX Medical, 150 Calle Iglesia, Suite A, San Clemente CA, 92672 and gases were provided by Linde Gas Therapeutics GmbH, Mittenheimer Straße 62, 85764 Oberschleißheim, Germany. ROX Medical and Linde Gas Therapeutics GmbH did not have any influence on the study design, data collection and analysis or interpretation of data.

Trial registry: ClinicalTrials.gov; No.: NCT00886639; URL: www.clinicaltrials.gov.

Department of Respiratory Medicine and Pulmonary Rehabilitation Schoen Klinik Berchtesgadener Land Malterhoeh 1 83471 Schoenau am Koenigssee Germany

Department of Respiratory Medicine and Pulmonary Rehabilitation, Schoen Klinik Berchtesgadener Land, Schoenau am Koenigssee, Germany

Department for Prevention, Rehabilitation and Sports Medicine, Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany

Department of Pneumology and Critical Care Medicine, University of Marburg, Marburg, Germany

Department of Pneumology and Critical Care Medicine, University of Marburg, Marburg, Germany

Department of Pneumology and Critical Care Medicine, University of Marburg, Marburg, Germany

Department of Pneumology and Critical Care Medicine, University of Marburg, Marburg, Germany

Department of Research and Education, CIRO+, Center of Expertise for Chronic Organ Failure, Horn, The Netherlands

REVAL - Rehabilitation Research Center, BIOMED - Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium

Department of Respiratory Medicine and pulmonary rehabilitation, Schoen Klinik Berchtesgadener Land, Schoenau am Koenigssee, Germany

Department of Pulmonary Rehabilitation, University of Marburg, Germany

Corresponding author: Inga Jarosch (MSc) Department of Respiratory Medicine and Pulmonary Rehabilitation Schoen Klinik Berchtesgadener Land Malterhoeh 1 83471 Schoenau am Koenigssee Germany.


Copyright 2016, . All Rights Reserved.


Chest. 2016. doi:10.1016/j.chest.2016.11.044
Text Size: A A A
Published online

Abstract

Background  The acute effect of supplemental oxygen during exercise has been shown to differ largely among patients with COPD. It is unknown what the oxygen response is influenced by.

Methods  In a randomized and single-blinded fashion, 124 COPD patients underwent one 6-minute walk test on supplemental oxygen (6MWTO2) and one on compressed room air (6MWTRA) after a practice 6MWT. Both gases wedre delivered via standard nasal prongs (2 liters/min). For analyses, patients were stratified based on PaO2 values: (a) 34 patients with resting hypoxemia (HYX), (b) 43 patients with exercise-induced hypoxemia (EIH) and (c) 31 normoxemic patients (NOX) were compared.

Results  Oxygen supplementation resulted in an increase of 6-minute walk distance (6MWD) in the total cohort (+27±42m, p<0.001) and in the subgroups of HYX (+37±40m, p<0.001) and EIH (+28±44m, p<0.001), but not in NOX patients (+15±43m, p=0.065). 42% of HYX and 47% of EIH patients improved 6MWD to a clinical relevant extent (≥30m) by using oxygen. These oxygen responders were characterized by significantly lower 6MWDRA compared to patients without a relevant response (306±106m vs. 358±113m, p<0.05). Although SpO2 was significantly higher during 6MWTO2 compared to 6MWTRA in all 3 subgroups, it dropped below 88% during 6MWTO2 in 73.5% of HYX patients.

Conclusions  In contrast to NOX patients, HYX and EIH generally benefit from supplemental oxygen by increasing exercise capacity. However, less than half of them reached the threshold of clinical relevant improvements. These oxygen responders were characterized by significantly lower exercise capacity levels.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543