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Correspondence |

Cancer and OSA: Beyond Hypoxia FREE TO VIEW

Maurizio Marvisi, MD
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FINANCIAL/NONFINANCIAL DISCLOSURES: None declared.

Department of Internal Medicine and Respiratory Diseases, Istituto Figlie di San Camillo, Cremona, Italy

CORRESPONDENCE TO: Maurizio Marvisi, MD, Via Filzi 56, Cremona, Italy, 26100


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(6):1411-1412. doi:10.1016/j.chest.2016.08.1472
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I have read with great interest and pleasure the excellent review by Martínez-García et al entitled “Cancer and OSA: Current Evidence from Human Studies” published in CHEST (August 2016). The authors shed light on this important and aporetical topic.

I was concerned about one issue not addressed adequately in the analysis: the role of sleep fragmentation on the innate and adaptive immune systems. In the literature, there are old and new data showing the impact of poor sleep and OSA in decreasing not only circulating monocytes but also natural killer cells, which play a key role in cancer biology and in other conditions such as autoimmune diseases.,, Furthermore, there is evidence that poorer global sleep quality is associated with shorter telomere length in CD8+ and CD4+ lymphocytes.

References

Martínez-García M.A. .Campos-Rodriguez F. .Barbè F. . Cancer and OSA: current evidence from human studies. Chest. 2016;150:451-463 [PubMed]journal. [CrossRef] [PubMed]
 
Born J. .Lance T. .Hansen K. .et al Effects of sleep and circadian rhythm on human circulating immune cells. J Immunol. 1997;58:4454-4463 [PubMed]journal
 
Geiger S.S. .Fagundes C.T. .Siegel R.M. . Chrono-immunology: progress and challenges in understanding links between the circadian and immune systems. Immunology. 2015;146:349-358 [PubMed]journal. [CrossRef] [PubMed]
 
Gaotswe G. .Kent B.D. .Carrigan M.A. .et al Invariant natural killer T cell deficiency and functional impairment in sleep apnea: link to cancer comorbidity. Sleep. 2015;38:1628-1634 [PubMed]journal
 
Pather A.A. .Gurfein B. .Moran P. .et al Tired telomeres: poor global sleep quality, perceived stress, and telomere length in immune cell subset in obese men and woman. Brain Behav Immun. 2015;47:155-162 [PubMed]journal. [CrossRef] [PubMed]
 

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References

Martínez-García M.A. .Campos-Rodriguez F. .Barbè F. . Cancer and OSA: current evidence from human studies. Chest. 2016;150:451-463 [PubMed]journal. [CrossRef] [PubMed]
 
Born J. .Lance T. .Hansen K. .et al Effects of sleep and circadian rhythm on human circulating immune cells. J Immunol. 1997;58:4454-4463 [PubMed]journal
 
Geiger S.S. .Fagundes C.T. .Siegel R.M. . Chrono-immunology: progress and challenges in understanding links between the circadian and immune systems. Immunology. 2015;146:349-358 [PubMed]journal. [CrossRef] [PubMed]
 
Gaotswe G. .Kent B.D. .Carrigan M.A. .et al Invariant natural killer T cell deficiency and functional impairment in sleep apnea: link to cancer comorbidity. Sleep. 2015;38:1628-1634 [PubMed]journal
 
Pather A.A. .Gurfein B. .Moran P. .et al Tired telomeres: poor global sleep quality, perceived stress, and telomere length in immune cell subset in obese men and woman. Brain Behav Immun. 2015;47:155-162 [PubMed]journal. [CrossRef] [PubMed]
 
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