0
Correspondence |

Response FREE TO VIEW

Juan F. Masa, MD, PhD; Jaime Corral, MD; Javier Gómez-de-Terreros, MD, PhD; María-Ángeles Sánchez-Quiroga, MD; Babak Mokhlesi, MD, FCCP
Author and Funding Information

FINANCIAL/NONFINANCIAL DISCLOSURES: See earlier cited article for author conflicts of interest.

aPulmonary Section, San Pedro de Alcántara Hospital, Cáceres, Spain

bPulmonary Section, Virgen del Puerto Hospital, Plasencia, Spain

cDepartment of Medicine, Section of Pulmonary and Critical Care, University of Chicago, Chicago, IL

dCIBER de enfermedades respiratorias (CIBERES), Madrid, Spain

CORRESPONDENCE TO: Juan F. Masa, MD, PhD, Pulmonary Section, San Pedro de Alcántara Hospital, Avda. Pablo Naranjo S/N, 10003 Cáceres, Spain


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(6):1409-1410. doi:10.1016/j.chest.2016.08.1468
Text Size: A A A
Published online

We agree with Dr Monneret and colleagues that our findings of a cardioprotective effect of OSA severity (as measured by the oxygen desaturation index) in patients with OHS should be considered preliminary in nature and taken as hypothesis generating. It is important to note that our analytic approach using multivariate regression modeling cannot adjust for all possible confounders. As such, using a biomarker such as high-sensitivity troponin would be of significant value to provide further insights into whether OSA severity is associated with a lower rate of cardiovascular morbidity in patients with OHS. Ultimately, if this association is confirmed in future studies, there is a great interest to understand the molecular mechanisms resulting in cardiovascular protection and whether it has clinical implications.

References

Masa J.F. .Corral J. .Romero A. .et al Protective cardiovascular effect of sleep apnea severity in obesity hypoventilation syndrome. Chest. 2016;150:68-79 [PubMed]journal. [CrossRef] [PubMed]
 

Figures

Tables

References

Masa J.F. .Corral J. .Romero A. .et al Protective cardiovascular effect of sleep apnea severity in obesity hypoventilation syndrome. Chest. 2016;150:68-79 [PubMed]journal. [CrossRef] [PubMed]
 
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543