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Editorial |

Nontuberculous Mycobacterial Disease Therapy: Take It to the Limit One More Time

David E. Griffith, MD, FCCP; Timothy R. Aksamit, MD
Author and Funding Information

FINANCIAL/NONFINANCIAL DISCLOSURES: None declared.

aUniversity of Texas Health Science Center, Tyler, TX

bDivision of Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, MN

CORRESPONDENCE TO: David E. Griffith, MD, FCCP, University of Texas Health Science Center, 11937 US Hwy 271, Tyler, TX 75708


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(6):1177-1178. doi:10.1016/j.chest.2016.07.015
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Extract

All too often we are reminded that essentially nothing about nontuberculous mycobacterial (NTM) disease is easy or simple, and the role of drug susceptibility/resistance is no exception. Many nontuberculous mycobacteria causing disease display a counterintuitive and frustrating disparity between in vitro drug susceptibility test results and in vivo response to specific antimicrobial agents. This NTM characteristic has been attributed to innate resistance factors that are frequently not reflected in the minimum inhibitory concentration of the antimicrobial agent for the organism., The inducible macrolide resistance (erm) gene in Mycobacterium abscessus subspecies abscessus is one such factor., Innate resistance is also unavoidable.

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