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Original Research |

Validation of the exhaled breath temperature measure: reference values in healthy subjects

Giovanna E. Carpagnano; Maria P. Foschino-Barbaro; Corrado Crocetta; Donato Lacedonia; Valerio Saliani; Luigi Davide Zoppo; Peter J. Barnes
Author and Funding Information

3Department of Medical and Surgical Sciences, Institute of Respiratory Diseases, University of Foggia – Italy

1Section of Statistics, Faculty of Economics, University of Foggia

2Airway Disease Section, National Heart and Lung Institute, Imperial College London, Royal Brompton Hospital, London, UK

Address correspondence Dr Giovanna Elisiana Carpagnano Institute of Respiratory Diseases, Department of Medical and Surgical Sciences, University of Foggia, Italy.


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016. doi:10.1016/j.chest.2016.11.013
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Abstract

Background  Exhaled breath temperature (EBT) is a new non-invasive method for the study of inflammatory respiratory diseases with a potential to reach clinical practice. However, few studies, and mainly derived from small, paediatric populations, are available on the validation of the method and the range of normal values is not well established.The aim of this study was to measure EBT values in an Italian population of 298 (45.2±15.5 yrs, 143 male, FEV1 97.2±5.8%, FVC 98.4±3.9%) selected from 867 adult volunteers, in order to define reference values in healthy subjects and to analyse the influence of individual and external variables on this parameter.

Methods  We measured EBT with a X-halo PRO device to different ambient temperature that ranged from 0 to 38°C

Findings  We report reference value of EBT in healthy Caucasian never smoker subjects. EBT values are strongly influenced by the external temperature and to a lesser extent by gender.

Interpretation  These data provide reference values in a large population of healthy never smokers subjects for measuring EBT as a basis for future studies. Our results are a contribution to the promotion of the EBT from bench to bed side.

Fundings  No funding was provided for this review.


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