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Original Research |

Adult Bronchiectasis Patients: A First Look at the United States Bronchiectasis Research Registry

Timothy R. Aksamit, MD; Anne E. O’Donnell, MD; Alan Barker, MD; Kenneth N. Olivier, MD; Kevin L. Winthrop, MD; M. Leigh Anne Daniels, MD MPH; Margaret Johnson, MD; Edward Eden; David Griffith, MD; Michael Knowles, MD; Mark Metersky, MD; Matthias Salathe, MD; Byron Thomashow, MD; Gregory Tino, MD; Gerard Turino, MD; Betsy Carretta, MPH; Charles L. Daley, MD
Author and Funding Information

Summary conflict of interests

TRA has participated in clinical trials sponsored by Bayer, Aradigm, and Insmed but has not received any personal or research support.

AEO is a PI / received grant support for clinical trials for Aradigm, Bayer, and Insmed and consultant for Bayer, Novartis, and Xellia Pharmaceuticals

AB is a consultant and PI for clinic research study for Bayer

KNO’s employer, NIAID, had a Cooperative Research and Development Agreement with Insmed, Inc

KLW has received grant support from Insmed and is a consultant for Bayer.

LAD has no conflicts.

MJ has no conflicts.

EE has no conflicts.

DG has received support as a consultant for Aradigm/Grifols

MK has no conflicts.

MM participated and received support for clinical trials for Aradigm and Bayer and consultant for Aradigm/Grifols

MS has received grant support for clinical trials with Aradigm, Insmed, Gilead, Pharmaxis, and JHP Pharmaceuticals and consultant for Insmed.

BT has no conflicts.

GTino has been a consultant for Aradigm /Grifols and Bayer.

GTurino has no conflicts.

BC has no conflicts.

CLD received research support from Insmed

Funding information – The study was funded by the COPD Foundation and, in part (KNO), by the Intramural Research Program of the NHLBI NIH

Corresponding Author: Timothy R. Aksamit, MD, Mayo Clinic, Pulmonary Disease and Critical Care Medicine, 200 First St., SW, Rochester, MN 55905.


Copyright 2016, . All Rights Reserved.


Chest. 2016. doi:10.1016/j.chest.2016.10.055
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Abstract

Objective  We sought to describe the characteristics of adult bronchiectasis patients enrolled in the United States Bronchiectasis Research Registry (BRR).

Methods  The BRR is a database of non-cystic fibrosis bronchiectasis (NCFB) patients enrolled at 13 sites within the United States. Baseline demographic, spirometric, imaging, microbiologic, and therapeutic data were entered into a central web-based database. Patients were subsequently analyzed by the presence NTM.

Results  We enrolled 1826 patients between 2008 and 2014. Patients were predominantly female (79%), white (89%), and never smokers (60%) with a mean age 64±14 years. Sixty-three percent of the patients had a history of NTM disease or NTM isolated at baseline evaluation into the BRR. NTM patients were older, predominantly female, and had bronchiectasis diagnosed at a later age than those without NTM. Gastroesophageal reflux (GERD) was more common in those with NTM whereas asthma, primary immunodeficiency and primary ciliary dyskinesia were more common in those without NTM. Fifty-one percent of patients had spirometric evidence of airflow obstruction. NTM patients were more likely to have diffusely dilated airways and tree-in-bud abnormalities. Pseudomonas and Staphylococcus aureus isolates were less commonly cultured among patients with NTM. Bronchial hygiene measures were used more often in those with NTM; whereas antibiotics used for exacerbations, rotating oral antibiotics, steroid use, and inhaled bronchodilators were more commonly used in those without NTM.

Conclusion  Adult bronchiectasis patients enrolled in the US BRR are described with differences noted in demographic, radiographic, microbiologic, and treatment variables based on stratification of the presence of NTM.


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