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Original Research |

USA Hospitalizations for Malignant Pleural Effusions - Data from the 2012 National Inpatient Sample

Niloofar Taghizadeh, PhD; Marc Fortin, MD; Alain Tremblay, MDCM
Author and Funding Information

Conflict of interest:

Dr. Tremblay serves as a consultant to CareFusion/BD Inc. All others declare no conflict of interest.

Funding information:

Calgary Interventional Pulmonary Medicine Research Fund

An abstract of this study has been accepted for publication and slide presentation at the 2016 CHEST conference.

1Division of Respiratory Medicine, University of Calgary and Alberta Thoracic Oncology Program

Corresponding Author: Dr. Alain Tremblay, Division of Respiratory Medicine, Cumming School of Medicine, University of Calgary. 3330 Hospital Drive NW, Calgary, AB, Canada, T2N 4N1.


Copyright 2016, . All Rights Reserved.


Chest. 2016. doi:10.1016/j.chest.2016.11.010
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Abstract

Background  Malignant pleural effusions (MPE) are a common complication of advanced malignancy, but little is known regarding their prevalence and overall burden on a population level.

Methods  We conducted a retrospective analysis of MPE associated hospitalizations using the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample, Agency for Healthcare Research and Quality (HCUP-NIS 2012). Cases were included if MPE was coded as a primary or secondary diagnosis or if an unspecified pleural effusion was coded in addition to a diagnosis of cancer with either of these being the primary diagnosis.

Results  A weighted sample of 126,825 (0.35 %) admissions for MPE was identified among the 36,484,846 weighted admissions included in the database in 2012. Of these admissions, 70,750 (55.8 %) were for female patients. The median (interquartile range (IQR)) age at admission was 68.0 (58.4-77.2). Lung (37.8%), breast (15.2%), hematologic (11.2%), GI tract (11.0%), and gynecologic (9.0%) cancers were the most common primary malignancies associated with MPE. The median (IQR) length of stay was 5.5 (2.7-10.1) days and the inpatient mortality rate was 11.6%. Median (IQR) hospitalization total charges were $42,376 (21,618-84,679). In the multivariate analyses, female gender, large fringe counties residential area, Medicare insurance and Elective type of admission were independently associated with a lower risk of inpatient mortality.

Conclusions  There is a considerable inpatient burden and high inpatient mortality associated with MPE in the United States with potential demographic, geographic and socioeconomic disparities.


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