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Translating Basic Research Into Clinical Practice |

Epithelial Derived Cytokines in Asthma

Patrick D. Mitchell, MD; Paul M. O’Byrne, MD, FCCP
Author and Funding Information

PDM has no conflict of interest to declare.

POB reports grants and personal fees from AstraZeneca, personal fees from Chiesi, grants from Novartis, personal fees from Boehringer Ingelheim, personal fees from GSK, personal fees from MedImmune, personal fees from Merck, personal fees from Abbott, grants from Amgen, grants from Genentech, grants from Axican outside the submitted work.

Firestone Institute of Respiratory Health and the Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada

Author for correspondence: Paul M. O’Byrne, Rm 2E1, McMaster University Medical Center, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.


Copyright 2016, . All Rights Reserved.


Chest. 2016. doi:10.1016/j.chest.2016.10.042
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Abstract

The interaction between the airway epithelium and the inhaled environment is crucial to understanding the pathobiology of asthma. Several studies have identified an important role of airway epithelial-derived cytokines, interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), in asthma pathogenesis. These cytokines have been described as “epithelial-derived alarmins” that activate and potentiate the innate and humoral arms of the immune system in the presence of actual or perceived damage. Each of the three epithelial-derived alarmins has been implicated in the pathobiology of inhaled allergen-induced airway responses. The best evidence, to date, exists for TSLP, in that a human monoclonal antibody (hMab), which binds TSLP and prevents its engagement with its receptor, resolves airway inflammation in allergic asthmatic subjects and attenuates allergen-induced airway responses. Better understanding the roles that the epithelial-derived alarmins play and how they influence airway immune response may allow the development of novel therapeutics for asthma treatment.


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