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An update on lymphocyte subtypes in Asthma and Airway Disease

Daniel M. Moldaver, BSc; Mark Larché, PhD; Christopher D. Rudulier, PhD
Author and Funding Information

Disclosure

M. Larché is a co-founder, and consultant of Circassia Ltd., a stockholder of Circassia Pharmaceuticals PLC,a founding scientist and consultant of Adiga Life Sciences Inc. and has received research support from both of these companies. ML consulted for UCB and Aravax Pty in the 12 months prior to publication of this article. DM and CD declare no conflict of interest

1Firestone Institute for Respiratory Health, St. Joseph’s Healthcare, Divisions of Respirology and Clinical Immunology & Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada

2Division of Respirology, Critical Care and Sleep Medicine, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

Correspondence address: Dr. Mark Larché, Firestone Institute for Respiratory Health, Divisions of Clinical Immunology & Allergy and Respirology, Department of Medicine, McMaster University, T2131-1, 2nd Floor, Juravinski Tower, St. Joseph's Hospital Healthcare, 50 Charlton Avenue East, Hamilton, ON, L8N 4A6.


Copyright 2016, . All Rights Reserved.


Chest. 2016. doi:10.1016/j.chest.2016.10.038
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Abstract

Inflammation is a hallmark of many airway diseases. Improved understanding of the cellular and molecular mechanisms of airway disease will facilitate the transition in our understanding from phenotypes to endotypes, thereby improving our ability to target treatments based on pathophysiology. For example, allergic asthma has long been considered to be driven by an allergen-specific Th2 response. However, clinical and mechanistic studies have begun to shed light on the role of other cell subsets in the pathogenesis and regulation of lung inflammation. In this review, we discuss the importance of different lymphocyte subsets to asthma and other airway diseases, while highlighting the growing evidence that asthma is a syndrome that incorporates many immune phenotypes.


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