Lung transplantation has evolved into a life-saving treatment with improved quality of life for patients with end-stage respiratory failure unresponsive to other medical or surgical interventions. With improving survival rates, the number of lung transplant recipients with pre-existing and post-transplant comorbidities that require attention continues to increase. A partnership between transplant and non-transplant care providers is necessary to deliver comprehensive and optimal care for transplant candidates and recipients. The goals of this partnership include timely referral and assistance with transplant evaluation, optimization of co-morbidities and preparation for transplantation, the management of common post-transplant medical comorbidities, immunization, screening for malignancy and counseling for a healthy lifestyle to maximize the likelihood of a good outcome. We aim to provide an outline of the main aspects of the care of lung transplant candidates and recipients for non-transplant physicians and other care providers.