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Translating Basic Research Into Clinical Practice |

Dendritic cells in human lung disease: recent advances

John W. Upham, MBBS PhD; Yang Xi, PhD
Author and Funding Information

CONFLICT OF INTEREST

The authors have no conflicts of interest.

JWU is supported by grants from the National Health and Medical Research Council of Australia.

aSchool of Medicine, The University of Queensland, Translational Research Institute (TRI), Woolloongabba, Brisbane, Australia

bDepartment of Respiratory Medicine, Princess Alexandra Hospital, Brisbane, Australia

Corresponding author: Professor John W. Upham School of Medicine The University of Queensland Level 5 West, Translational Research Institute, 37 Kent St, Woolloongabba QLD 4102, Brisbane Australia.


Copyright 2016, . All Rights Reserved.


Chest. 2016. doi:10.1016/j.chest.2016.09.030
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Abstract

Dendritic cells (DC) are potent antigen presenting cells. Because of their particular ability to initiate and regulate cell mediated and humoral immune responses, there is considerable interest in the role that DC play in the pathogenesis of various lung diseases, especially those in which there is an excessive immune response to specific antigens (as in asthma) or a deficient immune response (as in lung cancer). A number of DC subpopulations have been defined in the lungs including myeloid or conventional DC that initiate T-cell immunity and antibody production, and plasmacytoid DC that have an important role in anti-viral immunity and immune tolerance. Though an extensive body of literature has documented the role that DC play in experimental models of lung disease, this review will highlight recent advances in our understanding of DC function in human disease, including asthma, COPD, anti-microbial immunity and lung cancer. The future is likely to see new approaches whereby antigens and small molecules are targeted to receptors on particular DC subpopulations in order to modify pulmonary immune responses.


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