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Contemporary Reviews in Sleep Medicine |

Pediatric OSAS Morbidity Biomarkers: The Hunt is Finally On!

Leila Kheirandish-Gozal, MD, MSc; David Gozal, MD, MBA, FCCP
Author and Funding Information

Conflict of Interest: The authors have no conflict of interest to declare.

Funding Sources: LKG is supported in part by a grant from the National Institutes of Health (1R01HL130984-01).

Section of Pediatric Sleep Medicine, Department of Pediatrics, Biological Sciences Division, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637

Corresponding author: Leila Kheirandish-Gozal, MD, MSc, Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, 5841 S. Maryland Avenue, Office C-113 /MC2117, Chicago, IL 60637-1470, USA;


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016. doi:10.1016/j.chest.2016.09.026
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Abstract

Since the initial report 40 years ago on pediatric obstructive sleep apnea syndrome (OSAS) as a distinct and prevalent clinical entity, substantial advances have occurred in the delineation of diagnostic and treatment approaches. However, despite emerging and compelling evidence that OSAS increases the risk for cognitive, cardiovascular and metabolic end-organ morbidities, routine assessment of such morbidities is seldom conducted in clinical practice. One of the major reasons for such discrepancies resides in the relatively labor-intensive and onerous steps that would be required to detect the presence of any of such morbidities, further adding to the already elevated cost of diagnosing the disorder. To circumvent these obstacles, the search for biomarker signatures of pediatric OSA and its cognitive and cardiometabolic consequences was launched and considerable progress has occurred since then. Here, we review the current evidence for the presence of morbidity-related biomarkers among children with OSAS, and explore future opportunities in this promising arena.


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