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Original Research |

Bronchiectasis severity is an independent risk factor for vascular disease in a Bronchiectasis Cohort

Ieuan Edward Shepherd Evans; Pallavi Bedi, MD; Tom M. Quinn; Adam T. Hill, MD
Author and Funding Information

Summary of conflicts of interest: none for authors

Funding: no external funding

1Dpt of Respiratory Medicine Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA, United Kingdom

2The University of Edinburgh/MRC Centre for Inflammation Research, The Queen's Medical Research Institute, 47Little France Crescent, Edinburgh, EH16 4TJ

Correspondence Prof. Adam T Hill.


Copyright 2016, . All Rights Reserved.


Chest. 2016. doi:10.1016/j.chest.2016.09.022
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Published online

Abstract

Background  There is increased interest in the association of vascular disease with COPD and pneumonia, but there is a lack of research in this area with patients with bronchiectasis.

Methods  A retrospective study of 400 patients attending a specialist bronchiectasis clinic in NHS Lothian, Edinburgh, UK between May 2013 and September 2014 was conducted. The study assessed the prevalence of vascular disease (ischemic heart disease, cerebrovascular disease, peripheral vascular disease and atrial fibrillation). Using multivariable models, independent risk factors were identified for vascular disease that developed following the diagnosis of bronchiectasis.

Results  The study included 400 patients. There was pre-existing vascular disease before the diagnosis of bronchiectasis in 44 patients (11%) and vascular disease occurred after the diagnosis of bronchiectasis after a mean of 9.4 years, 95% confidence interval (6.0-12.8) years in 45 patients (11%). Independent factors associate with all cause vascular disease after the diagnosis of bronchiectasis were male sex, hypertension, being on long term statin therapy and having moderate severity bronchiectasis or worse.

Conclusion  In conclusion, bronchiectasis severity is independently associated with the development of vascular disease after the diagnosis of bronchiectasis. Future studies addressing the impact of primary and secondary prevention are warranted.


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