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Transplantation: Preconditions and Outcomes in Lung Transplantation |

Impact of Pre-Transplant Kidney Function on Eary and Late Outcomes After Lung Transplantation

Amit Banga; Manish Mohanka; Jessica Mullins; Srinivas Bollineni; Vaidehi Kaza; Fernando Torres
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University of Texas Southwestern Medical Center, Dallas, TX


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):1309A. doi:10.1016/j.chest.2016.08.1425
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SESSION TITLE: Preconditions and Outcomes in Lung Transplantation

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: There is lack of data regarding the independent impact of pre-transplant kidney function on early and late survival among lung transplant (LT) recipients.

METHODS: We queried the United Network of Organ Sharing (UNOS) database for adult patients (≥ 18 years of age) undergoing LT between 1987 and 2013. We excluded patients with simultaneous dual organ transplantation and where recipient serum creatinine at the time of listing for transplantation was not available. Glomerular filtration rate (GFR) was estimated using the Modification of Diet in Renal Disease (MDRD) Study equation for all the patients. After initial exploratory analysis, study population was split into three groups (>90, 60-90 and <60 ml/min/1.73m2) based upon the estimated GFR and survival at 1 year, 3 years and 5 years was compared using Chi-square test. In addition, survival analysis was done using different cut-offs for GFR. Once the best cut-off was identified, we adjusted for potential confounders including donor and recipient demographics, year of transplant, underlying diagnosis, recipient functional status, ventilator or ECMO support at the time of LT, and lung allocation score (where available) using multivariate logistic regression analysis (MVLR) to determine independent association with 1 year, 3 year and 5 year survival.

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