Transplantation: Outcomes in Lung Transplantation Slide |

Age-Dependent Gender Disparities in Post-Lung Transplant Survival Among Patients With Idiopathic Pulmonary Fibrosis FREE TO VIEW

Shahid Sheikh, MD; Don Hayes, Jr., MD; Steven Kirkby, MD; Joseph Tobias, MD; Dmitry Tumin, PhD
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Ohio State University/Nationwide Children's Hospital, Columbus, OH

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;150(4_S):1306A. doi:10.1016/j.chest.2016.08.1422
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SESSION TITLE: Outcomes in Lung Transplantation Slide

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Monday, October 24, 2016 at 01:30 PM - 02:30 PM

PURPOSE: The influence of age and gender on survival after lung transplant in patients with idiopathic pulmonary fibrosis (IPF) is not well defined. This study was conducted to identify any such disparities.

METHODS: The United Network for Organ Sharing (UNOS) database was queried from 2005 to 2013 to identify IPF patients receiving lung transplant.

RESULTS: There were 6,677 patients receiving LTx between May 2005 and June 2015 who met the inclusion criteria, predominantly male (n=4,769, 71%). Within less than 1 year post-transplant, the survival curves of male and female recipients diverged, with male recipients having significantly worse survival as indicated by a log-rank test (p = 0.008). Univariate Cox proportional hazards regressions demonstrated no gender difference in survival below age 65 (HR = 1.051; 95% CI = 0.945, 1.168; p = 0.362) but a significant increase in mortality hazard associated with male gender among patients age 65 and older (HR = 1.161; 95% CI = 1.000, 1.347; p = 0.049). Multivariable Cox regression accounting for age moderation of the gender effect further demonstrated the emergence of a male disadvantage in post-transplant survival above age 65 years at transplantation.

CONCLUSIONS: In patients with IPF receiving lung transplant at >65 years of age, male gender is associated with significantly increased risk for death.

CLINICAL IMPLICATIONS: Referral for lung transplant in IPF need to be considered early in the disease course esepcially in males.

DISCLOSURE: The following authors have nothing to disclose: Shahid Sheikh, Don Hayes, Jr., Steven Kirkby, Joseph Tobias, Dmitry Tumin

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