Tobacco Cessation and Prevention: Tobacco Cessation and Prevention |

Association Between Ventilatory Pulmonary Function and Metabolic Syndrome Components in Predicting the Cardiovascular Risk in Symptomatic Smokers FREE TO VIEW

Ligia Puiu, MD; Roxana Nemes, MD; Ancuta Petrovan, MD; Ruxandra Ulmeanu, MD; Florin Mihaltan, MD; Oana Claudia Deleanu, MD
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Hospital of Pneumophthisiology, Baia-Mare, Romania

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;150(4_S):1295A. doi:10.1016/j.chest.2016.08.1410
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SESSION TITLE: Tobacco Cessation and Prevention

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: To assess the relationship between pulmonary function and components of metabolic syndrome in predicting the risk of cardiovascular disease among respiratory symptomatic adult subjects in an Out-patient Pulmonology Health Unit.

METHODS: 85 respiratory symptomatic adults, mean aged 52.9±9.7 year-old, were grouped in smokers (n=43) and nonsmokers (n=42). Demographic, anthropometric, plasma lipid profile {(total cholesterol-TC, low density lipoprotein cholesterol-LDLc, high density lipoprotein cholesterol-HDLc, triglycerides-TG, nonhigh density lipoprotein cholesterol-nonHDLc, very low density lipoprotein cholesterol-VLDL), by which were calculated lipid indices}, glycemia and glycated hemoglobin (HbA1c) levels were performed. All subjects underwent spirometry according to the international recommendations. Lung function was expressed as forced vital capacity (FVC% predicted), forced expiratory volume in one second (FEV1% predicted) and Forced Expiratory volume in 1 second/Forced Vital Capacity ratio (FEV1/FVC% predicted). Metabolic syndrome was defined using the criteria proposed by the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI). Cardiovascular disease risk was evaluated through Framingham Risk Score (FRS). Statistical analysis included Spearman correlations tests and one-way ANOVA test.

RESULTS: The mean value of glycemia, HbA1c, TG/HDLc ratio, atherogenic coefficient (AC) {(Non-HDLc)/HDLc} and FRS were statistically significant higher in smokers (p=0.03;p=0.004;p=0.03;p=0.03;p=0.002). In smokers patients correlations were found as follows between FEV1/FVC ratio and HDLc (r=0.23;p=0.02); FEV1 and HbA1c (r=-0.31;p=0.03), TG (r=-0.30;p=0.04); FVC and TC/HDL-c (Castelli Risk Index I) (r=-0.41;p=0.05), TG/HDL-c (r=-0.41; p=0.05).

CONCLUSIONS: Our findings indicated that individual components of metabolic syndrome like low HDL-C, high triglycerides, and glycemia were significantly associated with FEV1/FVC ratio, FEV1 and FVC in smokers. HbA1c may be add as an additional diagnostic criterion and could provide early information in subjects prone to develop metabolic syndrome.

CLINICAL IMPLICATIONS: A better understanding of the relationship between lung function and metabolic syndrome, as a complex disorder featuring inflammation, can better predict the risk of heart disease in smokers.

DISCLOSURE: The following authors have nothing to disclose: Ligia Puiu, Roxana Nemes, Ancuta Petrovan, Ruxandra Ulmeanu, Florin Mihaltan, Oana Claudia Deleanu

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