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Sleep Disorders: Sleep Disorders 1 |

The Link Between OSA and Lung Cancer: A Retrospective Case Control Study

Hussein Hussein, MD; Rami Jambeih, MD; Himanshu Bhardwaj, MD; George Salem, MD; Jean Keddissi, MD; Houssein Youness, MD
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Oklahoma University Health Sciences Center, Oklahoma City, OK


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):1264A. doi:10.1016/j.chest.2016.08.1378
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SESSION TITLE: Sleep Disorders 1

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: Lung cancer accounts for 30% of all cancer deaths in the United States each year. Chronic inflammation has been linked to various steps involved in tumorigenesis. Several pro-inflammatory gene products have been identified that mediate a critical role in suppression of apoptosis, proliferation, angiogenesis, invasion, and metastasis. Among these gene products are Tumor Necrosis Factor (TNF), Interleukin (IL)-1a, IL-1b, IL-6, IL-8, and IL-18. The expression of all these genes is mainly regulated by the transcription factor nuclear factor kappa B (NF-kB), which is constitutively active in most tumors. Apnea-induced hypoxia and reoxygenation generates reactive oxygen species, which activate NF-kB and increase the systemic inflammation. Significant higher levels of pro-inflammatory cytokines TNF-α and IL-6, as well as a decrease in anti-inflammatory cytokines such as IL-10 has been found in obstructive sleep apnea (OSA). Previous studies showed that overnight oxygen desaturation seen in patients with OSA is associated with increased cancer incidence and cancer related mortality; The purpose of this study was to determine if OSA is an independent risk for the development and dissemination of malignancy, including lung cancer.

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