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Sleep Disorders: Research Investigations in Obstructive Sleep Apnea |

Association Between Sleep-Disordered Breathing and Urinary Isoprostane Levels in a Community-Based Sample

Katherine Green, MD; Terese Hammond, MD; Dan Gottlieb
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University of Southern California, Los Angeles, CA


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):1259A. doi:10.1016/j.chest.2016.08.1373
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SESSION TITLE: Research Investigations in Obstructive Sleep Apnea

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Wednesday, October 26, 2016 at 08:45 AM - 10:00 AM

PURPOSE: Systemic oxidative stress, as evidenced by increases in urinary creatinine-indexed levels of 8-epi-PGF2a (urinary isoprostanes), has been increasingly implicated in mechanistic models linking moderate to severe sleep disordered breathing (SDB) with prevalent cardiovascular disease. Additionally, modulation of urinary isoprostane levels has also been demonstrated during both initiation and discontinuation of continuous positive airway pressure (CPAP) treatment for moderate to severe SDB. Little is known about the association of urinary isoprostanes with SDB of the severity typically found in a community-based cohort. We report significant associations between both apnea-hyponea index (AHI) and percent sleep time with oxyhemoglobin saturation < 90% (O2LT90) in a cohort of community dwelling adults enrolled in the Sleep Heart Health Study.

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