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Respiratory Care: Chest Infections |

Evaluation of Aspergillus Galactmannan, β-D-glucan, and Two Different Aspergillus-PCR Tests Using Bronchoalveolar Lavage Fluid for Diagnosis of Chronic Pulmonary Aspergillosis

Naohisa Urabe, PhD; Susumu Sakamoto; Go Sano; Hiroshige Shimizu; Yasuhiko Nakamura; Yujiro Takai; Sakae Homma
Author and Funding Information

Toho University Omori Medical Center, Tokyo, Japan


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):1244A. doi:10.1016/j.chest.2016.08.1356
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SESSION TITLE: Chest Infections

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: To explore the more sensitive method for diagnosis of chronic pulmonary aspergillosis (CPA) using bronchoalveolar lavage fluid (BALF).

METHODS: We evaluated the Aspergillus galactmannan (GM), β-D-glucan (βDG) and two different Aspergillus-PCR assays by BALF samples from 18 patients with CPA group and 120 patients with control group who underwent bronchoscopic examination for making clinical diagnosis of pulmonary lesions. We also evaluated the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of each test. Receiver operating characteristic (ROC) analysis was performed to determine the cut off optical density index (ODI) of GM and βDG.

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