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Pulmonary Vascular Disease: Student/Resident Case Report Poster - Pulmonary Vascular Disease II |

Interleukin-6 as a Potential Therapeutic Target in PAH

Delamo Bekele, MBBS; Alicia Thomas, MD; Gail Kerr, MD; Patricia O'Neal, MD; Alem Mehari, MD
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Howard University Hospital, Washington, DC


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):1219A. doi:10.1016/j.chest.2016.08.1328
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SESSION TITLE: Student/Resident Case Report Poster - Pulmonary Vascular Disease II

SESSION TYPE: Student/Resident Case Report Poster

PRESENTED ON: Tuesday, October 25, 2016 at 01:30 PM - 02:30 PM

INTRODUCTION: Pulmonary arterial hypertension (PAH) is a poorly understood disease associated with increased morbidity and mortality. Multicentric Castleman disease (MCD) is an uncommon idiopathic lymphoproliferative disorder noted to result in an increase of interleukin-6 (IL-6) secretion and is associated with PAH in some patients. Recent data suggests that IL- 6 might promote pulmonary arteriole endothelial and smooth muscle proliferation leading to the development of PAH. We present a rare case of severe PAH due to rheumatoid arthritis (RA) complicated with MCD which responded to a combination of PAH targeted and biologic (Anti CD20) therapy.

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