SESSION TITLE: Student/Resident Case Report Poster - Pulmonary Vascular Disease II
SESSION TYPE: Student/Resident Case Report Poster
PRESENTED ON: Tuesday, October 25, 2016 at 01:30 PM - 02:30 PM
INTRODUCTION: Pulmonary arterial hypertension (PAH) is a poorly understood disease associated with increased morbidity and mortality. Multicentric Castleman disease (MCD) is an uncommon idiopathic lymphoproliferative disorder noted to result in an increase of interleukin-6 (IL-6) secretion and is associated with PAH in some patients. Recent data suggests that IL- 6 might promote pulmonary arteriole endothelial and smooth muscle proliferation leading to the development of PAH. We present a rare case of severe PAH due to rheumatoid arthritis (RA) complicated with MCD which responded to a combination of PAH targeted and biologic (Anti CD20) therapy.