RESULTS: We screened 592 articles through the PubMed search and many more through the resultant hand-search. PE and AF share many common risk factors, including old age, obesity, heart failure, and inflammatory states. PE may lead into AF through right-sided pressure overload and contributions from inflammatory cytokines or serotonin. AF might lead to right atrial appendage clot formation and thereby PE. Multiple studies indicate that AF can be seen as a presenting sign, during the early phase, or later in the course of recovery for patients with PE. Patients with AF are also at increased risk of developing PE; a risk that correlates with the CHA2DS2-VASc score. Antithrombotic therapy could be tailored based on presence and risk of both PE and AF.