University of Connecticut Health Center, Farmington, CT
Copyright 2016, American College of Chest Physicians. All Rights Reserved.
SESSION TITLE: Pulmonary Vascular Disease II
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM
PURPOSE: Pulmonary hypertension (PH) is reported to occur predominantly in patients with limited scleroderma while esophageal dysmotility is more common in diffuse scleroderma. The relation between mean pulmonary artery pressure (mPAP) and esophageal dilatation in scleroderma-associated pulmonary hypertension (Scl-PH) has not been studied. The objective of the study was to determine the relation between esophageal diameter with mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR) respectively in Scl-PAH patients.
METHODS: We reviewed the records of 26 patients with Scl-PAH followed at the PH center at our institution. Patient demographics, mPAPA and PVR were noted. Esophageal diameter was determined from CT imaging by averaging measurements at 3 levels- at the middle of the aortic arch, 2cm below the carina and just above the diaphragm. Studied variables were expressed as mean + SD. Pearson’s test for linear correlation was used to determine the association between mPAP and PVR respectively with esophageal diameter in Scl-PAH patients. p< 0.05 was deemed statistically significant.
RESULTS: Mean age was 67+ 15 years; 77% were females; 70% had limited disease. Mean PAP was 36.5 + 10 mm Hg; mean PVR was 553 + 360 dynes.sec/cm5. Mean esophageal diameter was 20.4 + 5.7 mm. There was significant correlation between mean PAP and esophageal diameter (r = -0.436; p=0.05) but no significant correlation between PVR and esophageal diameter (r = -0.004; p=0.09).
CONCLUSIONS: There appears to be a significant correlation between esophageal dilatation and mPAP in patients with Scl-PAH.
CLINICAL IMPLICATIONS: Esophageal involvement is less common in patients with scleroderma-associated pulmonary hypertension which is likely related to their limited disease.
DISCLOSURE: The following authors have nothing to disclose: Massa Zantah, Adarsha Selvachandran, Vanessa Yap, Debapriya Datta, Raymond Foley
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