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Pulmonary Vascular Disease: Pulmonary Vascular Disease II |

Early Detection of PAH in Patients With Systemic Connective Tissue Disease

Hikmet Al-Hiti; Vojtech Melenovsky, PhD; Josef Kautzner
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Institute for Clinical and Experimental Medicine, Prague, Czech Republic


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):1181A. doi:10.1016/j.chest.2016.08.1290
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SESSION TITLE: Pulmonary Vascular Disease II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: Dyspnoea is the most common symptom of pulmonary arterial hypertension (PAH ). Up to 75 % of patients with PAH are diagnosed in advanced stages of the disease. Patients with PAH associated with systemic connective tissue (CTD) have a poor prognosis, especially patients with systemic sclerosis. Despite modern therapy is a maximum 3 -year survival less favorable than in other forms of PAH 51 % vs 87%. Early stages of PAH are characterized by abnormal hypertensive response of pulmonary circulation to exercise. The aim of our study was to examine exercise-induced changes in invasive pulmonary hemodynamics in patients with CTD and compare them to other patients with dyspnoea of unknown etiology.

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