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Pulmonary Vascular Disease: Pulmonary Vascular Disease I |

Prostacyclin Therapy Suppresses Plasma BNP Levels Independent of Pulmonary Hemodynamic Effects in Patients With PAH

Samuel Belok, MD; Sabnam Shakya; Corey Ventetuolo, MD; James Klinger, MD
Author and Funding Information

Alpert Medical School of Brown University, Providence, RI


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):1171A. doi:10.1016/j.chest.2016.08.1280
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SESSION TITLE: Pulmonary Vascular Disease I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: Plasma BNP level is a widely used biomarker to assess disease severity in patients with pulmonary arterial hypertension (PAH). However, the effect of PAH medications on plasma BNP levels is not known. We have observed that many PAH patients on prostacyclin therapy have remarkably low plasma BNP levels despite severely elevated pulmonary arterial (PA) pressure. The purpose of this study, was to determine if prostacyclin treatment lowers plasma BNP levels in PAH patients independent of its effect on pulmonary hemodynamics.

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